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Results from this trial suggested that after 28 days of treatment, the setmelanotide group demonstrated a significant mean weight reduction of 3.48 kg from baseline, accompanied by a significant decrease in mean waist circumference of 5.83 cm
Tirzepatide did not demonstrate detectable attenuation of weight reduction-induced decreases in sleeping or 24-h energy expenditure, but there was a reduction in respiratory exchange ratio in the tirzepatide treatment arm compared with that in the placebo arm, consistent with an increase in fat oxidation
doi: 10.1016/j.afres.2024.100682 154 Maldonado-CervantesE.Huerta-OcampoJ
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