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Loprinzi CL, et al

Regulation of Atp7a RNA contributes to differentiation-dependent Cu redistribution in skeletal muscle cells

these can originate from intrinsic factors or from the acquisition of mobile genetic elements through processes such as horizontal gene transfer 62,63

Safety, Monitoring, and When to Reconsider This Approach Metformin is generally well-tolerated but can cause gastrointestinal side effects and vitamin B12 depletion over time