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Finally, 38 eligible RCTs were used in the current systematic review and meta-analysis, (Reference Ahmad Merza Mohammad31Reference van het Hof, de Boer, Wiseman, Lien, Westrate and Tijburg68) among which 19 articles assessed the impact of green tea on CRP, (Reference Rondanelli, Gasparri and Perna32,Reference Hadi, Alipour and Aghamohammadi37Reference Azizbeigi, Stannard and Atashak40,Reference Shin, Lee and Seo42,Reference Nogueira, Nogueira Neto, Klein and Sanjuliani46Reference Hussain, Habib Ur and Akhtar48,Reference Lee, Charng, Tseng and Lai50,Reference Borges, Papadimitriou, Duarte, Lopes de Faria and Lopes de Faria51,Reference Mielgo-Ayuso, Barrenechea, Alcorta, Larrarte, Margareto and Labayen54,Reference Liu, Huang, Huang, Chen, Chiu and Hsu55,Reference Bogdanski, Suliburska, Szulinska, Stepien, Pupek-Musialik and Jablecka60Reference Mohammadi, Hosseinzadeh Attar and Karimi63,Reference Fukino, Ikeda, Maruyama, Aoki, Okubo and Iso65,Reference De Maat, Pijl, Kluft and Princen67) 13 articles on TAC, (Reference Bazyar, Hosseini and Saradar36,Reference Azizbeigi, Stannard and Atashak40,Reference Venkatakrishnan, Chiu and Cheng41,Reference Tabatabaee, Alavian and Ghalichi44,Reference Soeizi, Rafraf, Asghari-Jafarabadi, Ghaffari, Rezamand and Doostan45,Reference Hadi, Pourmasoumi, Kafeshani, Karimian, Maracy and Entezari49,Reference Kuo, Lin, Bernard and Liao52,Reference Spadiene, Savickiene and Ivanauskas53,Reference Lasaite, Spadiene, Savickiene, Skesters and Silova56,Reference Mousavi, Vafa, Neyestani, Khamseh and Hoseini57,Reference Suliburska, Bogdanski, Szulinska, Stepien, Pupek-Musialik and Jablecka59,Reference Bogdanski, Suliburska, Szulinska, Stepien, Pupek-Musialik and Jablecka60,Reference van het Hof, de Boer, Wiseman, Lien, Westrate and Tijburg68) 11 articles on MDA, (Reference Naderifar, Gangeh, Mehri and Kazemi33,Reference Azizbeigi, Stannard and Atashak40,Reference Tabatabaee, Alavian and Ghalichi44,Reference Soeizi, Rafraf, Asghari-Jafarabadi, Ghaffari, Rezamand and Doostan45,Reference Hadi, Pourmasoumi, Kafeshani, Karimian, Maracy and Entezari49,Reference Kuo, Lin, Bernard and Liao52,Reference Spadiene, Savickiene and Ivanauskas53,Reference Mousavi, Vafa, Neyestani, Khamseh and Hoseini57,Reference Li, Chen and Aldini64,Reference Erba, Riso, Bordoni, Foti, Biagi and Testolin66,Reference van het Hof, de Boer, Wiseman, Lien, Westrate and Tijburg68) 10 articles on IL-6, (Reference Ahmad Merza Mohammad31,Reference El-Elimat, Qasem and Al-Sawalha34Reference Bazyar, Hosseini and Saradar36,Reference Bagheri, Rashidlamir and Ashtary-Larky39,Reference Azizbeigi, Stannard and Atashak40,Reference Nogueira, Nogueira Neto, Klein and Sanjuliani46,Reference Mombaini, Jafarirad, Husain, Haghighizadeh and Padfar47,Reference Basu, Du and Sanchez62,Reference De Maat, Pijl, Kluft and Princen67) 8 articles on TNF, (Reference Ahmad Merza Mohammad31,Reference Kondori, Ghaleh and Hosseini35,Reference Bagheri, Rashidlamir and Ashtary-Larky39,Reference Azizbeigi, Stannard and Atashak40,Reference Nogueira, Nogueira Neto, Klein and Sanjuliani46,Reference Mombaini, Jafarirad, Husain, Haghighizadeh and Padfar47,Reference Bogdanski, Suliburska, Szulinska, Stepien, Pupek-Musialik and Jablecka60,Reference De Maat, Pijl, Kluft and Princen67) 7 articles on GPX, (Reference Naderifar, Gangeh, Mehri and Kazemi33,Reference El-Elimat, Qasem and Al-Sawalha34,Reference Venkatakrishnan, Chiu and Cheng41,Reference Spadiene, Savickiene and Ivanauskas53,Reference Basu, Betts, Mulugeta, Tong, Newman and Lyons58,Reference Erba, Riso, Bordoni, Foti, Biagi and Testolin66,Reference van het Hof, de Boer, Wiseman, Lien, Westrate and Tijburg68) 5 articles on SOD, (Reference El-Elimat, Qasem and Al-Sawalha34,Reference Venkatakrishnan, Chiu and Cheng41,Reference Maeda-Yamamoto, Nishimura and Kitaichi43,Reference Spadiene, Savickiene and Ivanauskas53,Reference van het Hof, de Boer, Wiseman, Lien, Westrate and Tijburg68) and two articles on IL-1
When caught early, while the melanoma is still localized and thin, surgery is often curative
However, given that orforglipron will be a prescription medication, physicians could potentially prescribe it off-label for diabetes prior to formal diabetes approval, a common practice in the GLP-1 space
