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No evidence of bioaccumulation has been observed in rats, mice, or humans

Am J Med Genet A 2013

Protective effects of ascorbic acid and garlic extract against lead-induced apoptosis in developing rat hippocampus

The effect was dose-dependent and distinct from PDE5 inhibitors because it works centrally, through hypothalamic MC4R activation rather than peripheral vasodilation (Hadley, 2005)