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In BAC systems, granular activated carbon (GAC) acts as a filter medium, providing a large surface area for adsorption and biofilm formation

This interaction triggers c-Met phosphorylation and activates downstream signaling cascades including the PI3K/AKT and MAPK/ERK pathways, which are fundamental to neuronal survival, dendritic arborization, and synapse formation

This could occur from long-term folic acid supplementation, as well as for other reasons

In aging, when melatonin output diminishes, this synchronization is weakened contributing to internal desynchrony and various functional impairments (Dufoo-Hurtado et al., 2020)