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Some studies conducted in rodents, with exanatide and liraglutide, showed an association regarding the development of thyroid C-cell tumors after long exposures to overtherapeutic doses ( in vivo studies in cynomolgus monkeys administering liraglutide showed no effect on the relative fraction of C cells in the thyroid gland after 87 weeks

There are no large-scale randomized controlled trials evaluating its cosmetic tanning efficacy or long-term safety in healthy populations

doi: 10.1093/eurheartj/ehad192

Neurology is particularly high stakes: the EVOKE and EVOKE+ Phase 3 trials of semaglutide in early Alzheimers disease, due in 202526, will be the first large-scale cognitive readouts