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On the positive side, selective GLP-1 receptor agonism avoids the glucagon receptor-mediated hepatic glucose output and potential ketogenic effects that complicate dual agonist approaches

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Jordan Feigenbaum and Austin Baraki work through the full evidence base on overtraining syndrome the taxonomy, the attempted studies, the six competing mechanistic theories, the biomarker failures, and what's actually happening when a lifter can't make progress

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