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In preclinical research, the profile of ipamorelin effects and dosing is characterised by a selective, pulsatile release of growth hormone without any meaningful rise in cortisol or prolactin

Treatment regimen estimand This estimand is used to assess the average treatment effect of bimagrumab, semaglutide or bimagrumab plus semaglutide for all randomized participants at week 48, regardless of treatment adherence and/or premature discontinuation of study treatment or placebo

Induced pancreatic cell proliferation and beta cell neogenesis were also seen in the rats that received treatment