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This approach has been designed to determine the maximum suggested starting dose, even though lower starting doses may also be suitable in some first-in-human clinical trials

Humans cannot produce nitric oxide from nitrate without these bacteria ( Research has shown that mouthwash kills the oral bacteria needed to produce nitric oxide for up to 12 hours ( This leads to a decrease in nitric oxide production and, in some instances, an increase in blood pressure ( The detrimental effects of mouthwash on nitric oxide production may even contribute to the development of diabetes, which is characterized by malfunctions in insulin production or action

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A: No, it does not show direct cause-and-effect