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212,213 Likewise, turmeric and ginger, though safe in culinary doses, may exert hepatotoxic or uterotonic effects when consumed in excess, particularly in sensitive individuals or during pregnancy

Additionally, Gyps inhibit the activation of the Toll-like receptor 4/NF-B signaling pathway and the TGF-1/SMAD2/SMAD4 signaling pathway in orbital fibroblasts, exerting anti-inflammatory and antioxidant effects (163)

However in most clinical trials or studies using melatonin, it is well accepted that in general melatonin lacks toxic adverse events, and it is a safe drug at most of the usual tested doses from 0.5 to 5 mg/d (118)

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