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Circulation 116 , 18321844 (2007)

4 Discussion The serum serotonin levels were low before L-carnitine, L-carnitine supplementation was associated with a robust increase in peripheral serotonin and reduction of fatigue, and there was a statistically significant correlation between serum serotonin and fatigue levels in both patient groups

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Beyond its approved indication, PT-141 has been investigated and used off-label for male erectile dysfunction, particularly in men who don't respond to PDE5 inhibitors or have contraindications to their use