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MTHFR is one of the most important enzymes in the folate pathway

Curr Opin Chem Biol 28:174180 Dubowchik GM, Firestone RA, Padilla L, Willner D, Hofstead SJ, Mosure K, Knipe JO, Lasch SJ, Trail PA (2002) Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity

This has motivated in part the development histidine- and carboxylate-specific probes that can be used in parallel alongside of thiol-specific probes, which when jointly deployed, may well approach full coverage of the metalation status of the metalloproteome

3 Comorbid characteristics of chronic constipation and depression 3.1 Epidemiological associations 3.1.1 Comorbidity prevalence data Multiple large-scale epidemiological studies have confirmed that a significant bidirectional association exists between chronic constipation and depression