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Healthcare professionals increasingly recognize obesity as a chronic medical condition requiring long-term management instead of temporary dieting approaches

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M2 outnumbers M3 in gastrointestinal smooth muscle cells, however in vitro studies suggest that M3 receptors are primarily responsible for mediating excitatory effects of acetylcholine on gastrointestinal contractility ( On the other hand, gut peptides, such as incretins, are important regulators of gastrointestinal motility

[DOI] [PubMed] [Google Scholar] 33.De Gaetano A, Mingrone G, Castagneto M, Calvani M