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in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )

There is no risk of significant fluid absorption

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244 Additionally, somatostatin can inhibit gastrointestinal activity, reducing the secretion of pancreatic enzymes and gastric acid, thereby indirectly decreasing the demand for glucagon