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In addition, other studies have also demonstrated the involvement of TRP channels in paclitaxel-induced pain, which are well known to be predominantly expressed on this subpopulation of DRG neurons

Multidisciplinary team input This article aims to support clinicians to care for people with CKD or those who may have risk factors for CKD and does not provide exhaustive advice for managing people with kidney failure and advanced comorbid conditions that occur with CKD

Subcutaneous administration suffers from: Lower bioavailability Variable absorption Different pharmacokinetics Which means the systemic exposure of DSIP via subcutaneous administration is not equivalent to what is achieved with intravenous infusion

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