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Even an increased cardiovascular risk for DPP4 inhibitors was discussed, since in the SAVOR-TIMI 53 trial, a significant increased hospitalization due to heart failure in the saxagliptin-treated group was observed

T4 is converted to T3 in the body, but this doesnt always happen, due to numerous factors such as stress, nutrient deficiencies, and others so we often continue to feel exhausted despite having normal T4 levels

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PTMs such as phosphorylation and acetylation are labile and sub-stoichiometric, thus requiring additional sample processing considerations (e.g., phosphatase inhibitors) to avoid artifacts and enrich low-abundance PTMs