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Theres no reason to believe that the increased mitochondrial biogenesis, the activation of mitochondrial proteins, the antioxidant enzyme production are not happening to some degree, even with the smallest levels of GLP-1s, he says

The increased activity of -secretases and concurrent reduction in the activity of -secretase may partially explain why melatonin treatment results in diminished A levels in the brains of both sporadic and transgenic animal models of AD [55,56,57]

For anyone researching the broader connections between GLP-1 and energy levels , metabolic function , and metabolic rate , the gut-brain axis provides a framework for understanding how gut-level interventions can produce brain-level effects