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After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

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These challenges include variations in Exos composition due to differences in stem cell origin, cultivation methods, and isolation techniques [236]

Dose escalation study in diet-induced obese male rats Male Wistar rats (Ex-4 group, n = 4