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Moreover, the administration of albiglutide preserved myocardial viability and decreased cardiac lactate production after ischemia-reperfusion injury in rats.46 Intraperitoneal administration of liraglutide before the coronary artery occlusion procedure in mice also decreased the size of the infarct area, probably through the inhibition of caspase-3 activation in cardiomyocytes.42 Interestingly, increased cardiac cell survival in response to treatments based on GLP-1 had a significant impact on cardiac function, as was shown in most of the studies mentioned, in the setting of both ischemia-reperfusion and HF (Table 2).25,34,40,42,4451 Studies of the cytoprotective effects of GLP-1 and therapies based on GLP-1 in experimental ex vivo and in vivo models

2017 DOI: 10.1186/s12876-017-0652-3 PMID: 28789631 Honda Y, Kessoku T, Sumida Y, et al

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Rybelsus may have other interactions