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Hyperinsulinemic-euglycemic clamps were performed in 12-week-old Dpp4 +/+ , Dpp4 / , Dpp4 fl/fl , and Dpp4 hep/ mice subjected to 1216 weeks of HFHC diet

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The action of GLP-1 and GIP on the pancreas causes a reduction in glucagon secretion that results in diminished hepatic glucose production

Other important ZIPs include Zip8, which is involved in T cell activation and IFN- expression [45], and Zip14, which plays a role in zinc mobilization during infection and acute-phase responses [46]