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J Biol Chem (1987) 262:897580

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Introduction Autism spectrum disorder (ASD) is a behaviorally defined disorder that is estimated to affect up to 1 in 45 individuals in the United States (Zablotsky et al., Over the last two decades, there has been growing evidence that ASD is associated with impairments in key fundamental physiological processes of the body (Rossignol and Frye, However, just because metabolic abnormalities are associated with a disorder such as ASD, it does not mean that they are causative or that even correcting them may have an effect