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As with other GLP-1 receptor agonists, the most common side effects of semaglutide reported during the Wegovy clinical trials include things like: Advertisement Nausea Vomiting Diarrhea Constipation Abdominal pain Upset stomach It's also common to experience gastrointestinal side effects when you increase your semaglutide dose as it can take some time for your body to adjust

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