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It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
Pharmacological modulation of reactive oxygen species (ROS) improves the airway hyperresponsiveness by shifting the Th1 response in allergic inflammation induced by ovalbumin
Ingredients: Water, Isopentyldiol, Tripropylene Glycol, Pentylene Glycol, Propanediol, Glutathione, Niacinamide, Methyl Gluceth-20, Methylpropanediol, Hippophae Rhamnoides Water, Diethoxyethyl Succinate, Sodium Citrate, Betaine, Nicotinamide Mononucleotide, Glycerin, Butylene Glycol, Xanthan Gum, Hydroxyacetophenone, Citric Acid, Ethylhexylglycerin, Coptis Japonica Root Extract, Disodium EDTA, 1,2-Hexanediol, Dextrin, Hydrogenated Lecithin, Theobroma Cacao Seed Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Lactococcus Ferment Lysate, Ceramide NP, Fructooligosaccharides, Cyperus Rotundus Root Extract, Ascorbic Acid, Nicotinamide Adenine Dinucleotide, 3-O-Ethyl Ascorbic Acid, Sodium Chloride, Hippophae Rhamnoides Fruit Juice
Clin Cosmet Investig Dermatol 10, 147153.CrossRefGoogle ScholarPubMed Tong, J, Fitzmaurice, PS, Moszczynska, A, et al
