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Preproglucagon Gene Expression in Pancreas and Intestine Diversifies at the Level of Post-Translational Processing

79 Chronic hyperglycemia activates mTORC1 and reduces mTORC2 activity 157 in islet cells, which leads to the translocation of FOXO1 to nucleus and less nuclear PDX1, resulting in reduced insulin synthesis and secretion and impaired cell mass 80,158 (Fig

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