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Stimulating effects of H 2 S on glycolytic metabolism in cancer cells have been demonstrated to result from per-sulphidation of lactate dehydrogenase (LDH, particularly the LDH-A isoform) 149,150 and glyceraldehyde-3-phosphate dehydrogenase, although the functional consequences of per-sulphidation of the latter appear to be controversial
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Etiology and Pathophysiology Outside of the neonatal period, childhood constipation is usually functional (i.e., there is no evidence of an organic condition)
Both the exendin-P5 and oxyntomodulin bound complexes also exhibited less persistent interactions between ICL2 and the N and hns1/S1 region of G s and between the N-terminal portion of H8 with G , whereas the remainder of interactions were largely consistent across the different complexes (Supplemental Figure 13, Supplemental Tables 4-5)
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