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A randomised placebo-controlled trial (RCT) including 42 participants with schizophrenia, who were experiencing an acute phase of symptomatology, were randomly assigned to receive up to 2 g/d of NAC plus up to 6 mg/d of risperidone for 8 weeks as an adjunct intervention
The intake does not use a validated PHQ-2 or PHQ-9 depression instrument (mental health is covered by the suicidal/homicidal and eating disorder gates), does not split personal vs family history into separate questions on MTC or MEN-2 (theyre combined in a single you or a family member prompt), and does not include a dedicated opioid or broader substance-use screen beyond alcohol dependence
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Using a mouse macrophage cell line, the authors show that IFN-gamma and endotoxin increase both nitric oxide (NO) production and bactericidal activity
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