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10.1155/2017/6871089 [DOI] [PMC free article] [PubMed] [Google Scholar] Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R (2011) The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

FIGURE 2 Discussion This case is the first known report of successful stabilization of an aggressive metastatic clear cell sarcoma, under the administration of targeted multi kinase inhibitor and immuno-therapy for 24 months