In line with the latter, GLP-1 have been shown to protect from ischaemia/reperfusion injuries in isolated perfused rat hearts ( It should be noted that one of the two major DPP-IV-generated truncated forms of GLP-1 (GLP-1 [9-36amide]) has been shown to have direct beneficial cardiac effects in mice, which is representative of the hypothesis that a GLP-1R-associated response can be elicited also by these metabolites and thus not only via the classic incretin pathway ( Future perspectives In summary, the cardiovascular safety of all currently marketed GLP-1 RAs has been thoroughly established in large CVOTs (Sattar et al., 2021), of which some also suggested a substantial cardioprotective benefit
Where multiple technical replicates of an experiment were performed, trials from the same animal were averaged and handled as a single biological replicate for data analysis and visualization
Many EGCGs on the market come in ultra-purified versions, around 90%, but achieved through synthetic processing
To view a copy of this licence, visit About this article Cite this article Hepprich, M., Zillig, D., Florian-Reynoso, M.A