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A review: exploring synthetic schemes and structure-activity relationship (SAR) studies of mono-carbonyl curcumin analogues for cytotoxicity inhibitory anticancer activity

Erastin irreversibly inhibits system Xc , leading to sustained GSH depletion and amplification of cisplatin-induced oxidative damage, which ultimately triggers ferroptosis and overcomes cisplatin resistance (36)

GSH abolished this inhibitory effect and promoted the recovery of SLC7A11 and GPX4 levels (Fig

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