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10.1016/j.euroneuro.2021.04.014 29

These changes were accompanied by marked downregulation of junctional proteins zonula occludens-1 (ZO-1), Ecadherin, and occludin ( in vitro findings link ferroptotic signaling to impaired intercellular adhesion and increased epithelial permeability, suggesting a plausible mechanism for enhanced bacterial translocation into deeper periodontal tissues in vivo

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A possible explanation of vitamin E deficient intake observed in WEN could be an association with nutritional customs and behavioral habits, such as the low dietary consumption of nuts, wheat germ, sunflower seeds, and extra virgin olive oil [23]