Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, Elliott M, Sa S, Guo F, Wang L, Cao A, Guignabert C, Sollier J, Nickel NP, Kaschwich M, Cimprich KA, Rabinovitch M (2019) PPAR interaction with UBR5/ATMIN promotes DNA repair to maintain endothelial homeostasis
Diabetes Care 43(9):22082216
The primary endpoint is the time to the first occurrence of a composite primary outcome event, defined as a persistent eGFR decline (50% from baseline), reaching ESRD, renal death, or CV death
It is important to note, however, that these mechanisms have not yet been fully confirmed in large-scale human trials and should be regarded as working hypotheses rather than established facts