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Pemetrexed administered intraperitoneally at doses of 0.1 mg/kg/day to male mice (approximately 0.0006 times the recommended human dose based on BSA) resulted in reduced fertility, hypospermia, and testicular atrophy

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Risks and Side Effects While generally safe, vitamin B12 injections can have side effects or risks, such as: Mild pain, swelling, or redness at the injection site Dizziness, headache, or nausea Allergic reactions (rare) Hypokalemia (low potassium levels) in individuals with severe deficiency undergoing treatment People with allergies to cobalt or who have Lebers disease should avoid B12 injections unless specifically advised by a doctor