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This is because, in comparison to GLP-1, semaglutide has two amino acid substitutions, which makes it less vulnerable to degradation by the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) [97] and gives it the distinct advantage of increased albumin affinity [96]
A patient who loses 60 pounds over 18 months on tirzepatide will likely experience less hair impact than one who loses 60 pounds in 6 months through a very low calorie diet, even though neither used surgery
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