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It's important to note that weight loss may improve fertility, particularly in women with PCOS, so reliable contraception is essential if pregnancy is not desired

In contrast, other studies reported that smoking reduces serum uric acid levels and has a protective effect against the risk of gout 7-10

In this context, microbiota-targeted interventions such as fecal microbiota transplantation have been proposed as complementary strategies to restore microbial diversity and improve metabolic outcomes, highlighting the broader relevance of hostmicrobiome interactions in shaping antidiabetic drug efficacy (9)

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