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Los frmacos ms recientes, como la tirzepatida, son anlogos duales que contienen tanto GLP-1 como GIP, produciendo resultados superiores en control glucmico y reduccin de peso corporal

The cardiovascular benefits demonstrated with GLP-1 receptor agonists such as semaglutide (in the SUSTAIN-6 and SELECT trials) cannot automatically be extrapolated to retatrutide, and direct evidence is still awaited

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In order to restore the tissues integrity, not only do resident stem cells have to be activated, but also some differentiated cells must revert to a stem cell-like state and acquire mobility