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Oral versus injectable GLP-1 formulations Oral GLP-1 formulations like oral tirzepatide and oral semaglutide drops eliminate the injection site question entirely

Abdel-Qadir H, Akioyamen LE, Fang J, Pang A, Ha ACT, Jackevicius CA, Alter DA, Austin PC, Atzema CL, Bhatia RS, Booth GL, Johnston S, Dhalla I, Kapral MK, Krumholz HM , McNaughton CD, Roifman I, Tu K, Udell JA, Wijeysundera HC, Ko DT, Schull MJ, Lee DS

Discussion We report a large-scale GWAS of treatment response to GLP1 medications and identify a missense variant in GLP1R , which encodes the therapeutic target of semaglutide and tirzepatide that associates with BMI loss