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GLUTATHIONE IMPORT TO MITOCHONDRIA As indicated above, despite the fact that the concentration of mGSH is high, GSH is not synthesized de novo in the mitochondrial matrix, as this organelle lacks the enzymes required for GSH synthesis

In fact, they may contribute to the opposite effectbetter health and body functioning can sometimes aid in maintaining a healthy weight

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Due to the polarity of GSH, thiols, amino acids, and peptides, derivatization is often required for RP separation, extraction, or UV/fluorescence detection, using reagents like N-ethylmaleimide (NEM) [31, 50, 54], 5,5-dithiobis(2-nitrobenzoic acid) (Ellmans reagent) [33, 55], iodoacetic acid [56], orthophthalaldehyde [34, 35], monochlorobimane [49], or monobromobimane [35]