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Differences between randomized clinical trial patients and real-world initiators of the glucagon-like peptide 1 receptor agonist liraglutide

doi:10.1056/NEJMoa2301972 46

Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor