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While there are many reasons why someone could feel fatigued, B12 is a part of the picture and correcting the deficiency can greatly improve energy levels

[2] During a monotherapy clinical trial of topiramate in the treatment of epilepsy in adults, the following centrally-mediated effects were reported in patients receiving 50 mg per day vs

Fatigue, weakness, especially lightning bolt sensations type of pain, joint pain, muscle pain, cognitive impairment, anxiety unrelated to stressors (eg a physical anxiety without a life trigger), depersonalization / derealization, depression, skin sensitivity, emotional lability, thermal lability, vertigo, dizziness, nausea, vomiting - and more

However, despite widespread use of ivermectin over the past few decades for several indications, reports of resistance to date have been limited and contentious (Crump et al