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SNAC exposure did increase with decreases in hepatic function, with the greatest increase seen in patients with severe hepatic impairment (3.64 times higher than patients with normal hepatic function)

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The inflammatory markers monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor (TNF- ), were reduced by treatment with exendin-4 in response to lipopolysaccharide in cultured peritoneal macrophages harvested from mice [65]