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[6] [10] You should arrange a GP appointment if you experience: Persistent difficulty achieving or maintaining erections sufficient for sexual activity Sudden onset of erectile problems, especially if accompanied by other symptoms Reduced libido or changes in sexual desire Pain during erection or intercourse Concerns about fertility or reproductive health Psychological distress related to sexual function Your GP will conduct a thorough assessment including medical history, medication review, and examination

The long-term safety profile is well-characterized, and the cardiovascular benefit is proven through the SELECT trial

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Rigorous human studies are required to determine safety parameters, mechanistic specificity, and potential translational relevance before any clinical applications can be considered