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Mice with RBC-specific deletion of eNOS show no change in resting coronary blood flow but exhibit elevated systemic blood pressure, indicating that RBC-derived NO contributes to maintaining vascular tone ( Hemoglobin, the most abundant protein in RBCs, engages in dynamic interactions with NO, forming a range of redox-related derivatives, including methemoglobin (MetHb) and HbNO

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This effect is particularly relevant in tissues like brown and beige adipose tissue, where ERRs regulate thermogenic programs including uncoupling protein 1 (UCP1) expression

Glutathione content was quantified by HPLC per serving as stated on each product label