glutathione absorption rate Cellular concentration of glutathione ([GSH]cell)

Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

Anti-inflammation benefits

Yes, evidence is weak but lack of RCTs here is mostly an incentive problem

Similar manipulation of sensory inputs in the visual cortex, synaptic input deprivation by permanent lesion of the retina, induces the disappearance of a fraction of GABAergic boutons in few hours (Keck et al., 2011), suggesting that the rapid loss of functional inhibitory synapses may represent a general adaptive mechanism to decreased levels of synaptic activity that is conserved in different functional areas of the cortex