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Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28

This dual anti-inflammatory and pro-survival signaling complements the gene-level anti-inflammatory effects of GHK-Cu and the vascular protection afforded by BPC-157's nitric oxide production, creating coordinated suppression of destructive inflammation while preserving protective immune responses essential for optimal tissue repair

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SGLT2 inhibitors (sodium-glucose co-transporter-2 inhibitors) such as dapagliflozin, empagliflozin, or canagliflozin represent a different drug class with cardiovascular and renal benefits