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In addition to -cells, autophagy plays key roles in insulin-target tissues

However, more evidence is needed to clarify their systemic effects and controversial direct hepatic benefits

All claims relate to in-vitro and animal models only

Smoking cigarettes involves a substantial amount of free radicals that may degrade exogenous and endogenous antioxidants, as well as dysregulate monocytes and vascular smooth muscle cells [70] Endothelial nitric oxide synthase (eNOS)- derived nitric oxide plays a crucial role in regulating platelet accumulation, vasodilation, and maintaining stability between smooth muscle cell growth and proliferation