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Preclinical studies have shown that large doses of GLP-1RAs can reduce lipid deposition and plaque volume on the aortic surface of hyperglycemic mice via an AMPK-independent action in streptozotocin (STZ)-induced hyperglycemic and hyperlipidemic mice or type 1 diabetic rats [55]

Semaglutide is a medication primarily used for the treatment of type 2 diabetes and obesity, functioning as a GLP-1 receptor agonist to help regulate blood sugar levels and promote weight loss

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Contrarily, another 2019 meta-analysis of 17 RCTs did not support the benefits of CoQ 10 supplementation on the body weight and BMI of patients [108]