Nanoformulations, such as paclitaxel in nanocrystals (443), DOX in poly (aspartic acid) NPs (444), paclitaxel with phosphatidylserine lipid nanovesicles (445), and DOX loaded in magnetic silk fibroin-based NPs (446), also demonstrated efficacy against MDR cancer in several studies
Additional Therapies and Concerns A number of additional therapies have been shown to either modulate GSH status or glutathione-related enzymes, though lack extensive research
Therefore, this review will critically assess the hypothesis of whether, and under what circumstances, ferroptosis is a relevant mode of cell death following APAP overdose and other intrinsically toxic drugs
2017a, b, c)In addition, an aberrant gene expression profile is linked to the mitochondrial phenotype observed in DS, characterized by reduced respiratory efficiency, changes in mitochondrial morphology, altered oxidative metabolism, and impaired mitochondrial biogenesis (Izzo et al