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Front Endocrinol 10:431 Zhang Y, Han S, Kong M, Tu Q, Zhang L, Ma X (2021) Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration

Figure 11: Platelets and tumor cells modulate the immune response and increase the production of proinflammatory proteins (like cytokines) and reactive oxygen species [inflammation] (1 and 2)

Finally, we found that the E366G mutation in the SNIP1 FHA domain, which is linked to a neurodevelopmental disorder in the Amish, reduces binding to P-SF3B1 and to the activated spliceosome