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Skeletal muscle atrophy results from mitochondrial toxicity in denervated skeletal muscle, which can impair the scavenging of reactive oxygen species (ROS), leading to oxidative injury and the apoptosis of skeletal muscle cells [9, 10]

Suppression of glutaredoxin 1 is further associated with impaired terminal differentiation of airway macrophages resulting in impaired phagocytic function and altered inflammatory mediator release (5)

Mitochondrial morphology analysis The mitochondrial morphology of HCC and PCa cells was evaluated by transmission electron microscopy (FEI, Hillsboro, Oregon, USA) as described previously

and 55 C., followed by further cooling until incipient crystallisation