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Therefore, although semaglutide clearly induces a statistically significant weight loss, the clinical significance of this weight loss, with respect to reducing the risk of various weight-related comorbidities, is uncertain and we do not know the long-term efficacy, or harms, of semaglutide

Over weeks and months, this adds up to significant muscle loss that is extremely difficult to reverse

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Its point is that receptor density, insulin secretion capacity, and metabolic flexibility differ between people, which it says explains why dose requirements and side effect profiles vary so widely